Eddie Murphy

as Sherman Klump / Buddy Love / Granny Klump / Mama Klump / Papa Klump / Young Papa Klump / Ernie Klump / Lance Perkins

Janet Jackson

as Denise

Larry Miller

as Dean Richmond

John Ales

as Jason

Richard Gant

as Denise's Father

Anna Maria Horsford

as Denise's Mother

Melinda McGraw

as Leanne Guilford

Jamal Mixon

as Ernie Klump, Jr.