Vijay

as Thalapathy Vetri Kondan 'Vetri'

Pooja Hegde

as Kayal

Bobby Deol

as John Himler / Amrish Poojari

Mamitha Baiju

as Vijayalakshmi 'Viji'

Priyamani

as Sheela Rani

Prakash Raj

as Roja Rangasamy

Gautham Vasudev Menon

as Srikanth

Narain

as Kaleel