Hugh Jackman

as Tomás / Tom Creo / Tommy

Rachel Weisz

as Isabel / Izzi Creo

Ellen Burstyn

as Dr. Lillian Guzetti

Mark Margolis

as Father Avila

Stephen McHattie

as Grand Inquisitor Silecio

Fernando Hernández

as Lord of Xibalba

Cliff Curtis

as Captain Ariel

Sean Patrick Thomas

as Antonio