Meg Ryan

as Mary Haines

Annette Bening

as Sylvie Fowler

Debra Messing

as Edie Cohen

Jada Pinkett Smith

as Alex Fisher

Eva Mendes

as Crystal Allen

Candice Bergen

as Catherine Frazier

Cloris Leachman

as Maggie

India Ennenga

as Molly Haines