Yolande Moreau

as Séraphine Louis, dite Séraphine de Senlis

Ulrich Tukur

as Wilhelm Uhde

Anne Bennent

as Anne-Marie Uhde

Geneviève Mnich

as Mme Duphot

Nico Rogner

as Helmut Kolle

Adélaïde Leroux

as Minouche

Françoise Lebrun

as La mère supérieure

Hélène Hardouin

as La propriétaire