Gael García Bernal

as Ernesto "Che" Guevara de la Serna

Rodrigo de la Serna

as Alberto Granado

Mercedes Morán

as Celia de la Serna

Mía Maestro

as Chichina Ferreyra

Jean Pierre Noher

as Ernesto Guevara Lynch

Lucas Oro

as Roberto Guevara

Marina Glezer

as Celita Guevara

Sofia Bertolotto

as Ana María Guevara