Spencer Tracy

as Matt Drayton

Sidney Poitier

as John Prentice

Katharine Hepburn

as Christina Drayton

Katharine Houghton

as Joanna "Joey" Drayton

Cecil Kellaway

as Monsignor Ryan

Beah Richards

as Mrs. Prentice

Roy Glenn

as Mr. Prentice

Isabel Sanford

as Tillie