E. G. Daily

as Tommy Pickles (voice)

Nancy Cartwright

as Chuckie Finster (voice)

Kath Soucie

as Phil DeVille / Lil DeVille / Betty DeVille (voice)

Dionne Quan

as Kimi Watanabe-Finster (voice)

Tim Curry

as Nigel Thornberry (voice)

Joe Alaskey

as Lou Pickles (voice)

Tress MacNeille

as Charlotte Pickles (voice)

Michael Bell

as Drew Pickles / Charles 'Chaz' Finster, Sr. (voice)