Frank Welker

as Fred Jones / Scooby-Doo (voice)

Casey Kasem

as Shaggy Rogers (voice)

Heather North

as Daphne Blake (voice)

Nicole Jaffe

as Velma Dinkley (voice)

Candi Milo

as Charlene Otero / Museum Guide / Old Woman #1 (voice)

Maria Canals-Barrera

as Sofia Otero / Old Woman #2 (voice)

Jesse Borrego

as Luis Otero / Musician #2 / Suspicious Tourist (voice)

Brandon Gonzales

as Jorge Otero (voice)