Tom Papa

as El Superbeasto (voice)

Sheri Moon Zombie

as Suzi X (voice)

Paul Giamatti

as Dr. Satan (voice)

Rosario Dawson

as Velvet Von Black (voice)

Joe Alaskey

as Erik the Newscaster (voice)

Ken Foree

as Luke St. Luke (voice)

April Winchell

as Dame Grace Appleton / Liza / Babs / Dolly / Joan / Gloria / Scripty / Helga Strudel (voice)

Tom Kenny

as Rover / Otto / Old Man / Herbie (voice)