Ryan Reynolds

as Jerry Hickfang / Mr. Whiskers (voice) / Bosco (voice) / Deer (voice) / Bunny Monkey (voice)

Gemma Arterton

as Fiona

Anna Kendrick

as Lisa

Jacki Weaver

as Dr. Warren

Ella Smith

as Alison

Paul Chahidi

as Dennis Kowalski

Stanley Townsend

as Sheriff Weinbacher

Adi Shankar

as John