Emma Thompson

as Vivian Bearing

Audra McDonald

as Susie Monahan

Jonathan M. Woodward

as Dr Jason Posner

Christopher Lloyd

as Dr. Harvey Kelekian

Eileen Atkins

as Evelyn 'E.M' Ashford

Benedict Wong

as Fellow 2

Harold Pinter

as Mr. Bearing

Raffaello Degruttola

as Technician 1