Lionel Barrymore

as Dr. Josiah Glass

Jean Arthur

as Maria Theresa 'Terry' O'Reilly

Chester Morris

as Jeff Crane

Joseph Calleia

as Sonny 'Dinkie' Black

Paul Kelly

as Special Agent James Duff

Lewis Stone

as Prison Warden

Paul Hurst

as Rufe Parker

George E. Stone

as Butch