Kristen Wiig

as Alice Klieg

James Marsden

as Rich Ruskin

Linda Cardellini

as Gina Selway

Wes Bentley

as Gabe Ruskin

Jennifer Jason Leigh

as Deb Moseley

Alan Tudyk

as Ted Thurber

Tim Robbins

as Dr. Daryl Moffet

Joan Cusack

as Dawn Hurley