Jean Hersholt

as Dr. John Luke

Yvonne Dionne

as Yvonne, a Wyatt Quintuplet

Annette Dionne

as Annette, a Wyatt Quintuplet

Cécile Dionne

as Cécile, a Wyatt Quintuplet

Émilie Dionne

as Émilie, a Wyatt Quintuplet

Marie Dionne

as Marie, a Wyatt Quintuplet

June Lang

as Mary MacKenzie

Slim Summerville

as Constable Jim Ogden