Vincent Price

as Charles Dexter Ward / Joseph Curwen

Debra Paget

as Ann Ward

Lon Chaney Jr.

as Simon Orne

Frank Maxwell

as Dr. Marinus Willet / Priam Willet

Leo Gordon

as Edgar Weeden / Ezra Weeden

Elisha Cook Jr.

as Gideon Smith / Micah Smith

John Dierkes

as Benjamin West / Jacob West

Milton Parsons

as Jabez Hutchinson