John Barrymore

as Dr. Henry Jekyll / Mr. Edward Hyde

Brandon Hurst

as Sir George Carewe

Martha Mansfield

as Millicent Carewe

Charles Lane

as Dr. Richard Lanyon

Cecil Clovelly

as Edward Enfield

Nita Naldi

as Miss Gina

Louis Wolheim

as Music Hall Proprietor

Alma Aiken

as Extra (uncredited)