Fredric March

as Dr. Henry Jekyll / Mr. Edward Hyde

Miriam Hopkins

as Ivy Pearson

Rose Hobart

as Muriel Carew

Holmes Herbert

as Dr. John Lanyon

Halliwell Hobbes

as Brig. Gen. Sir Danvers Carew

Edgar Norton

as Poole

Tempe Pigott

as Mrs. Hawkins

Leonard Carey

as Briggs, Lanyon's Butler (uncredited)