Teyonah Parris

as Lysistrata

Nick Cannon

as Demetrius 'Chi-Raq' Dupree

Wesley Snipes

as Sean 'Cyclops' Andrews

Angela Bassett

as Miss Helen Worthy

Samuel L. Jackson

as Dolmedes

John Cusack

as Fr. Mike Corridan

Jennifer Hudson

as Irene

David Patrick Kelly

as General King Kong