Oscar Isaac

as Will Dempsey

Olivia Wilde

as Abby Dempsey

Annette Bening

as Dr. Cait Morris

Antonio Banderas

as Vincent Saccione

Samuel L. Jackson

as Self

Olivia Cooke

as Dylan Dempsey

Mandy Patinkin

as Irwin Dempsey

Jean Smart

as Linda Dempsey