Glenn Close

as Adrienne Pargiter

Frances McDormand

as Dr. Verstak

Pauline Collins

as Daisy 'Margaret' Drummond

Cate Blanchett

as Susan Macarthy

Julianna Margulies

as Topsy Merritt

Jennifer Ehle

as Rosemary Leighton-Jones

Wendy Hughes

as Mrs. Dickson

Johanna ter Steege

as Sister Wilhelminia