Tom Hanks

as Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry

Halle Berry

as Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym

Jim Broadbent

as Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2

Hugo Weaving

as Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie

Jim Sturgess

as Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother-in-Law

Bae Doona

as Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute

Ben Whishaw

as Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman

James D'Arcy

as Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist