Bob Hoskins

as Eddie Valiant

Christopher Lloyd

as Judge Doom

Joanna Cassidy

as Dolores

Charles Fleischer

as Roger Rabbit / Benny the Cab / Greasy / Psycho (voice)

Kathleen Turner

as Jessica Rabbit (voice) (uncredited)

Stubby Kaye

as Marvin Acme

Alan Tilvern

as R.K. Maroon

Richard LeParmentier

as Lt. Santino