Roberto Benigni

as Roberto (segment "Strange to Meet You")

Steven Wright

as Steven (segment "Strange to Meet You")

Joie Lee

as Good Twin (segment "Twins")

Cinqué Lee

as Evil Twin (segment "Twins") / Kitchen Guy (segment "Jack...")

Steve Buscemi

as Danny (segment "Twins")

Iggy Pop

as Iggy (segment "Somewhere in California")

Tom Waits

as Tom (segment "Somewhere in California")

Joseph Rigano

as Joe (segment "Those Things'll Kill Ya")