Clint Eastwood

as Manco

Lee Van Cleef

as Col. Douglas Mortimer

Gian Maria Volonté

as El Indio

Mara Krupp

as Mary

Luigi Pistilli

as Groggy, Member of Indio's Gang

Klaus Kinski

as Juan Wild - The Hunchback

Luis Rodríguez

as Manuel, Member of Indio's Gang

Benito Stefanelli

as Luke 'Hughie'